Comparison of Cervical Cytology and Colposcopic Biopsy Results in HPV non 16/18 Oncogenic Type Positive Patients at General Hospital in Singburi
Keywords:
colposcopy, cervical cytology, Human Papilloma Virus (HPV)Abstract
This retrospective study aims to compare cervical cytology results with colposcopic biopsy findings in patients positive for HPV non-16/18 type. The sample included 110 women aged 30 – 65 years who tested positive for HPV non-16/18 type and underwent cervical cytology and colposcopy at Inburi Hospital between October 1, 2020, and November 30, 2023. Data collected included general characteristics, cervical cytology results, and colposcopic biopsy findings. Descriptive statistics such as frequency, percentage, mean, and standard deviation were used, and the McNemar test was applied to assess the consistency between the two diagnostic methods.
The study found that in cases with normal or abnormal cervical cytology, colposcopic biopsy often revealed higher levels of abnormality, indicating a discrepancy between the two diagnostic methods. The McNemar test demonstrated a statistically significant difference between cervical cytology and colposcopic biopsy results (p < 0.001).
References
WHO. Cervical cancer 2022 [updated 22 February 2022. Available from: https://www.who.int/news-room/fact-sheets/detail/cervical-cancer.
National Cancer Institute, Department of Medical Services, Ministry of Public Health, Thailand. Hospital Based Cancer Registry 2016. Bangkok, Thailand; 2018.
Bruni L, Albero G, Serrano B, Mena M, Collado JJ, Gomez D et al. Human papillomavirus and related diseases in Thailand. HPV Information Centre [online]. 2017 [cited 2021 Oct 22]. Available from: https://hpvcentre.net/statistics/reports/THA.pdf
Sert ZS. Comparison of colposcopic biopsy results of cervical cytology-negative and HPV 16/18 or other high-risk HPV subtypes, Ann Med Res 2021;28(7):1366-70.
RTCOG. Cervical cancer screening [online]. 2021 Jan 22 [cited 2022 Jun 1]. Available from: http://www.rtcog.or.th/home/wp-content/uploads/2022/05/GY-64-017-1.pdf
Wright JD. Cervical intraepithelial neoplasia: Terminology, incidence, pathogenesis, and prevention 2022 [updated 6 July 2022. Available from: https://www.uptodate.com/contents/cervical-intraepithelial-neoplasia-terminology-incidence-pathogenesis-and-prevention?topicRef=3215&source=see_link.
Michael J. Campion KC. Preinvasive disease. In: Jonathan S. Berek NFH, editor. Barek and Hacker’s gynecologic oncology. 7 ed. China: Wolters Kluwer; 2021. p. 500-619.
Huh WK, Ault KA, Chelmow D, Davey DD, Goulart RA, Garcia FA, et al. Use of primary high-risk human papillomnavirus testing for cervical cancer screening: Interim clinical guidance. Gynecol Oncol 2015;136:178-82.
เกื้อหนุน บัวไพจิตร. ความสัมพันธ์ของการตรวจคัดกรองมะเร็งปากมดลูกกับผลการตรวจทางพยาธิวิทยาในโรงพยาบาลสกลนคร. วารสารโรงพยาบาลสกลนคร 2561;21(3):1-11.
สถาบันมะเร็งแห่งชาติ. แนวทางการคัดกรองมะเร้งปากมดลูกด้วยวิธี HPV DNA test. [อินเทอร์เน็ต] 2563 [เข้าถึงเมื่อ 15 พ.ย.66] เข้าถึงได้จาก http://www.nci.go.th/th/File_download/D/index/ptu/2563/2.
NHSO. HPV primary testing [online]. 2019 Jul 21 [cited 2020 Jul 20]. Available from: https://www.hfocus.org/content/2019/07/17388
Denizli R, Saki O, Angin AD, Cikman MS, Pirimoglu ZM. Colposcopic examination in cytology negative women who tested positive for non-16/18 HPV types. Journal of Istanbul Faculty Medicine 2019;82(4):212-8.
Annekathryn Goodman M, MPH, MSWarner K Huh, MDMark H Einstein, MD, MS, FACS, FACOG. Cervical cancer screening: Management of results 2022 [updated 18 November 2022. Available from: https://www.uptodate.com/contents/cervical-cancer-screening-management-of-results?source=history_widget.
Nayar R, Wilbur D. The pap test and Bethesda 2014. Acta Cytologica 2015;121-32.
Perkins RB, Guido RS, Castle PE, Chelmow D, Einstein MH, Garcia F, et al. 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors. J Low Genit Tract Dis. 2020;24(2):102-31.
ธวัชชัย วรพงศธร, สุรีย์พันธุ์ วรพงศธร. การคำนวณขนาดตัวอย่างสำหรับงานวิจัยโดยใช้โปรแกรมสำเร็จรูป G*Power Retrieve on January 20, 2019, Available from: http://advisor.anamai.moph.go.th/download/Journal_health//2561HEALTH41_/2HEALTH_Vol41No2_.02pdf.
ปาริชาติ โรจน์พลากร-กู๊ซ, ยุวดี ฤาชา. สถิติสำหรับงานวิจัยทางการพยาบาลและการใช้โปรแกรม SPSS for Windows. พิมพ์ครั้งที่ 3. กรุงเทพฯ: บริษัท จุดทอง จำกัด; 2555.
Banna EL, Eyd GA, Saeed R. High-risk human papillomavirus infection among women with pap smear tests negative for intraepithelial lesions or malignancy. Int J Med Public Health. 2014;4:102.
Sasaki Y, Iwanari O, Arakawa I, et al. Cervical Cancer Screening With Human Papillomavirus DNA and Cytology in Japan. Int J Gynecol Cancer 2017;27:523-9.
Aydogmus H, Aydogmus S. Comparison of Colposcopic biopsy results of patients who have cytomorphological normal but HPV 16-18 or other high-risk HPV subtypes positive. Asian Pac J Cancer Prev 2019;20:417-20.
Karaca İ, Öztürk M, Comba C, et al. Immediate biopsy of cervical cytology-negative and non-HPV-16/18 oncogenic types positive patients. Diagn Cytopathol 2018;46:326-30.
Vural NA, Koyan GN, Karadeniz O, Durmus SE, Kocaman, Turan H. (2021). Comparison of colposcopic biopsy results of non-HPV 16/18 Oncogenic type positive patients. Cam and Sakura Med J 2021;1(2):64-6
Chumnan K, Siriwan T, Jatupol S. Histopathological Outcomes of Women with Abnormal Cervical Cytology: a Review of Literature in Thailand. Asian Pacific Journal of Cancer Prevention, Vol 15, 2014: 6489-6494
ColMadendag İ, Madendag Y, Sahin E, Eraslan M, Acmaz G. Is colposcopic examination necessary in women with high risk HPV without HPV16/18? The Journal of Gynecology - Obstetrics and Neonatology 2018;15:102-105.
Ramírez AT, Valls J, Baena A, et al. Performance of cervical cytology and HPV testing for primary cervical cancer screening in Latin America: an analysis within the ESTAMPA study. Lancet Reg Health Am. 2023 Sep 20;26:100593.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Samutprakan Hospital Journal (SMPK HOS J)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
