Factors Associated with Mortality in Patients with Septic Shock
Keywords:
Factors affecting mortality, Shock, SepsisAbstract
Purpose: This study aimed to identify factors associated with mortality in patients diagnosed with septic shock.
Design: A retrospective cross-sectional study.
Method: This study used data from the medical record of patients diagnosed with septic shock who were admitted in Sawanpracharak Hospital between January 1, 2017, and December 31, 2023. A total of 313 patients were selected through simple random sampling. The data were initially analyzed using the chi-square test, and statistically significant variables were further examined through bivariate analysis to identify factors for inclusion in the multivariate model.
Main findings: The findings revealed that patient-related factors, health status–related factors, and treatment-related factors were significantly associated with mortality among patients with septic shock. Disease severity assessed using standardized scoring systems showed a statistically significant association with mortality. Patients with the most severe disease according to the SOS score had a mortality rate of 91.60% (OR 0.2, 95 % CI: 0.04-0.63). Similarly, patients with a MEWS score of 3–4 exhibited a mortality rate of 85.70% (OR 4.3, 95 % CI: 2.39-7.73). In terms of treatment-related factors, vasopressor use was associated with mortality, with a mortality rate of 70.60 % (OR = 0.80, 95 % CI: 0.27-0.73) observed among patients who did not receive vasopressor therapy (OR=0.32, 95 % CI: 0.14–20.65). In conclusion, disease severity indicators derived from standardized assessment tools, along with selected treatment-related factors, were significantly associated with mortality in patients with septic shock.
Conclusion and recommendations: The findings highlight the importance of utilizing standardized severity assessment tools for sepsis and early warning scores in evaluating patients, as well as the critical role of vasopressor use in the management of septic shock. The information derived from this study can be applied to guide clinical planning and patient monitoring, thereby enhancing the effectiveness of care for critically ill patients.
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