CORRELATION BETWEEN ANTIMICROBIAL RESISTANCE AND ANTIBIOTIC USE IN THUNGSONG HOSPITAL, NAKHON SI THAMMARAT PROVINCE
Keywords:
Antimicrobial, Antimicrobial Resistance, Amount of Antimicrobial useAbstract
BACKGROUND: Antimicrobial resistance of bacteria (AMR) is continuously increasing around the world. According to the Thailand Antimicrobial Resistance Management Strategic Plan, it is necessary to rely on effective, reliable, and comprehensive information to achieve the goal of controlling and preventing the spread of AMR. All of these require standardized microbiology labs, patient infectious disease databases, and patient-derived antimicrobial medication information.
Objectives: To study the relationship between antimicrobial use dosage and antimicrobial resistance in Thungsong Hospital, Nakhon Si Thammarat Province.
Method of study: Evaluating retrospective data. Antimicrobial resistance of four bacterial strains, namely Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumonia, from 2015-2021.
Results: P. aeruginosa was found to be susceptible to Ciprofloxacin. The percentage of resistant strains considerably declined in a downward direction (p = 0.021). K. pneumoniae is susceptible to Ertapenem, Gentamycin, and Meropenem in an increasing direction (p = 0.006, 0.037 and 0.016 respectively) and E. coli is susceptible to Meropenem and Piperacillin/Tazobactam. P. aeruginosa and K. pneumoniae were related in the same direction to the use of Ceftazidime (r = 0.84, p = 0.019 and r = 0.82, p = 0.023)
Conclusions: The increase in ceftazidime use may be due to an increase in the number of hospital stays and when correlated with antimicrobial resistance rates. It was found to be associated with P. aeruginosa and K. pneumoniae. Therefore, hospital should continue to increase long-term prevention and control measures for drug resistance.
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