The prevalence and risk factors study of peripheral artery disease in HIV patients. Kingnarai hospital.

Authors

  • Thananchai Kampee -

Keywords:

HIV patients, Peripheral Artery Disease (PAD)

Abstract

     This study was conducted as a cross-sectional study aimed to study the prevalence and risk factors of peripheral artery disease (PAD) among HIV patients at Kingnarai hospital. The sample group consisted of 330 HIV patients registered with the HIV counseling and antiretroviral (ARV) clinic at Kingnarai hospital. General patient information, ARV treatment, cardiovascular risk factors, and Ankle-Brachial Index (ABI) were collected. Data were analyzed using descriptive statistics to determine prevalence, presented as a percentage (Prevalence Rate) with a 95% confidence interval. Cox Regression was used to analyze risk factors associated with PAD.

     Results: Out of the 330 patients in this study, the majority were male (219 patients or 66.36%). The average age was 45.89 ± 1.48 years, and the average body mass index (BMI) was 22.38 ± 0.97. There were 26 patients diagnosed with PAD, resulting in a prevalence of 7.87%. The average results from physical examinations and laboratory tests showed that systolic and diastolic blood pressure were within normal ranges, while blood lipid levels were relatively high. ABI measurements indicated abnormalities on both the right and left sides (1.03 ± 4.31 and 1.01 ± 3.48, respectively), with the lowest values being 0.89 and 0.87, indicating PAD. Risk factors significantly associated with the occurrence of PAD included: male gender, BMI ≥ 23, smoking history, history of hypertension, history of coronary artery disease, CD4 count < 200, and receiving the TDF + 3TC + RPV drug regimen.

References

Ryom L, Lundgren JD, El-Sadr W, et al. Cardiovascular disease and use of contemporary protease inhibitors: the D:A:D international prospective multicohort study. lancet HIV. 2018;5(6):291-300.

กรมควบคุมโรค. สถานการณ์ แนวโน้มการแพร่ระบาดของเอชไอวีในประเทศไทย ปี 2565. https://ddc.moph.go.th/uploads/publish/1549120240328063459.pdf

Gutierrez F, Bernal E, Padilla S, Hernandez I, Masia M. Relationship between ankle-brachial index and carotid intima-media thickness in HIV-infected patients. Aids. 2008; 22: 1369-71.

Paraskevas KI, Mikhailidis DP. C-reactive protein (CRP): more than just an innocent bystander? Curr Med Res Opin. 2008;24:75-8

Athyros VG, Kakafika AI, Karagiannis A, Mikhailidis DP. Do we need to consider inflammatory markers when we treat atherosclerotic disease? Atherosclerosis. 2008;200:1-12.

Olalla J, Salas D, de la Torre J, Del Arco A, Prada JL, Martos F, et al. Ankle-brachial index in HIV infection. AIDS Res Ther. 2009; 66.

Bernal E, Masia M, Padilla S, Hernandez I, Gutierrez F. Low prevalence of peripheral arterial disease in HIV-infected patients with multiple cardiovascular risk factors. J Acquir Immune Defic Syndr. 2008;47:126-7.

Gutierrez F, Bernal E, Padilla S, Hernandez I, Masia M. Relationship between ankle-brachial index and carotid intima-media thickness in HIV-infected patients. Aids. 2008;22:1369-71. Olalla J, Salas D, de la Torre J, Del Arco A, Prada JL, Martos F, et al. Ankle-brachial index in HIV infection. AIDS Res Ther. 2009;6:6.

Palacios R, Alonso I, Hidalgo A, Aguilar I, Sanchez MA, Valdivielso P, et al. Peripheral arterial disease in HIV patients older than 50 years of age. AIDS Res Hum Retroviruses. 2008;24:1043-6.

Periard D, Cavassini M, Taffe P, Chevalley M, Senn L, Chapuis-Taillard C, et al. High prevalence of peripheral arterial disease in HIV-infected persons. Clin Infect Dis. 2008;46:761-7.

Qaqa AY, DeBari VA, Isbitan A, Mohammad N, Sison R, Slim J, et al. The role of postexercise measurements in the diagnosis of peripheral arterial disease in HIV-infected patients. Angiology.2011;62:10-4.

Sharma A, Holman S, Pitts R, Minkoff HL, Dehovitz JA, Lazar J. Peripheral arterial disease in HIV-infected and uninfected women. HIV Med. 2007;8:555-60.

Anderson KM, Odell PM, Wilson PW, Kannel WB. Cardiovascular disease risk profiles. American heart journal. 1991;121:293-8.

Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). Journal of vascular surgery. 2007;45 Suppl S:S5-67.

Xin Su. et,al. Antiviral treatment for hepatitis C is associated with a reduced risk of atherosclerotic cardiovascular outcomes: A systematic review and meta-analysis J Viral Hepat. 2021; 28(4):664-671.

ขวัญชัย ศุภรัตน์ภิญโญ และคณะ. การศึกษาความชุกและปัจจัยเสี่ยงของโรคหลอดเลือดส่วนปลายในผู้ป่วยเอชไอวี. https://www.rihes.cmu.ac.th/NCD/?p=421; 2558

Downloads

Published

2025-06-30

How to Cite

Kampee, T. . (2025). The prevalence and risk factors study of peripheral artery disease in HIV patients. Kingnarai hospital. Journal of Environmental and Community Health, 10(3), 251–256. retrieved from https://he03.tci-thaijo.org/index.php/ech/article/view/4491