บทบาทของอีพิเจเนติกส์ต่อการเกิดและการรักษาโรค ของเนื้อเยื่อในโพรงฟันและโรครอบปลายรากฟัน
Keywords:
การคงความมีชีวิตของเนื้อเยื่อในโพรงฟัน , การรักษาคลองรากฟัน , รีเจเนอเรทีฟเอ็นโดดอนติกส์, อีพิเจเนติกส์Abstract
ปัจจุบันมีแนวคิดในการพัฒนาวัสดุชีวภาพทางทันตกรรมที่มีเป้าหมายในการเสริมสร้างเนื้อเยื่อในโพรงฟัน (Pulp regenerative) เพื่อหลีกเลี่ยงการรักษาคลองรากฟันแบบดั้งเดิม (Root canal treatment) โดยหนึ่งในแนวคิดใหม่ คือ อีพิเจเนติกส์ (Epigenetics) ซึ่งเป็นกลไกการควบคุมการแสดงออกของยีนโดยไม่ได้เปลี่ยนลำดับดีเอ็นเอ (DNA) โดยกลไกนี้มีความเกี่ยวข้องกับกระบวนการอักเสบรวมถึงขั้นตอนการเปลี่ยนแปลงของเซลล์เพื่อไปทำหน้าที่ของเซลล์ต้นกำเนิดจากฟัน (Dental-derived stem cells) ซึ่งในปัจจุบันได้มีการศึกษาถึงเรื่องอีพิเจเนติกส์ในบทบาทต่องานเอ็นโดดอนติกส์มากขึ้น โดยมีการนำแนวคิดมาพัฒนาปรับใช้ในขั้นตอนการรักษาความมีชีวิตของเนื้อเยื่อในโพรงฟันหรือ รีเจเนอเรทีฟเอ็นโดดอนติกส์ รวมถึงโรครอบปลายรากฟัน เป็นต้น บทความนี้มีวัตถุประสงค์เพื่ออธิบายหลักการของอีพีเจเนติกส์ต่อเซลล์ โดยเฉพาะเซลล์เนื้อเยื่อในโพรงฟัน (Dental pulp cells) โดยเน้นในแง่มุมที่เกี่ยวกับ การนำมาใช้ในงานเอ็นโดดอนติกส์ต่อการรักษาโรคของเนื้อเยื่อในโพรงฟันและโรครอบปลายรากฟัน เพื่อเป็นองค์ความรู้นำไปปรับใช้หรือเป็นแนวทางในการนำไปต่อยอดงานวิจัยในอนาคต
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