Extrusion of calcium silicate-based root canal sealers into the inferior alveolar canal: A review of literature
Keywords:
apical extrusion, bioceramic root canal sealers, inferior alveolar canal, inferior alveolar nerve, mandibular canalAbstract
Calcium silicate-based root canal sealers (CSS) have transformed root canal treatment with their excellent properties. However, the risk of extrusion into the inferior alveolar canal (IAC) may lead to nerve injuries and significant morbidity. Multiple factors contribute to extrusion, including anatomical variability, over-aggressive canal preparation, and the high flowability of CSS. Both non-surgical and surgical management strategies are discussed. Non-surgical interventions, including those that employ corticosteroids, B vitamins, and analgesics, show promise in reducing inflammation and supporting nerve recovery. In contrast, surgical techniques, including material removal and nerve decompression, are reserved for severe cases. Early diagnosis through advanced imaging, such as cone-beam computed tomography (CBCT), is crucial for effective intervention. Clinicians should conduct thorough preoperative assessments and refine obturation methods to minimize extrusion risks. Further research and the development of standardized guidelines are necessary to manage sealer extrusion into the IAC, which will enhance endodontic practice and minimize the risk of permanent nerve damage.
References
Chong BS, Gohil K, Pawar R, Makdissi J. Anatomical relationship between mental foramen, mandibular teeth and risk of nerve
injury with endodontic treatment. Clin Oral Investig. 2017;21:381–7.
Castro R, Guivarc’h M, Foletti JM, Catherine JH, Chossegros C, Guyot L. Endodontic-related inferior alveolar nerve injuries: A review and a therapeutic flow chart. J Stomatol Oral Maxillofac Surg. 2018;119:412–8.
Reda R, Zanza A, Bhandi S, De Biase A, Testarelli L, Miccoli G. Surgical-anatomical evaluation of mandibular premolars by CBCT among the Italian population. Dent Med Probl. 2022;59:209–16.
Alazemi A, Muhairi EA, Alharbi N, Abdunabi F, Mashyakhy M, Chaudhry J, et al. Evaluation of Mental Foramen and Mandibular Canal Course and Location in an Emirati Subpopulation. Int Dent J. 2024;74:1142–50.
Wongwatanasanti N, Tungsawat P, Suksaphar W, Lertnantapanya S, Yodmanotham P. Root Canal Treatment and Demand for Continuing Education among Thai Dental Practitioners. Open Dent J. 2024;25;18:e18742106308012.
Chybowski EA, Glickman GN, Patel Y, Fleury A, Solomon E, He J. Clinical Outcome of Non- Surgical Root Canal Treatment Using a Singlecone Technique with Endosequence Bioceramic Sealer: A Retrospective Analysis. J Endod. 2018;44:941–5.
Tanompetsanga P, Tungsawat P. Microleakage in Immediate vs Delayed Post Space Preparation in Root Canals Filled with Bioceramicbased Root Canal Sealer. World J Dent. 2020;11:172–8.
Suksaphar W, Tungsawat P, Wongwatanasanti N, Lertnantapanya S, Yodmanothum P. Effect of Different Tapered Gutta-Percha Points on Push- Out Bond Strength of Two Root Canal Sealers. Eur J Gen Dent. 2025;27;s-0044-1800800.
Tanompetsanga P, Tungsawat P. Microleakage in Immediate vs Delayed Post Space Preparation in Root Canals Filled with Bioceramic-based Root Canal Sealer.World J Dent. 2020;11:172–8.
Chybowski EA, Glickman GN, Patel Y, Fleury A, Solomon E, He J. Clinical Outcome of Non- Surgical Root Canal Treatment Using a Singlecone Technique with Endosequence Bioceramic Sealer: A Retrospective Analysis. J Endod. 2018;44:941–5.
Zamparini F, Lenzi J, Duncan HF, Spinelli A, Gandolfi MG, Prati C. The efficacy of premixed bioceramic sealers versus standard sealers on root canal treatment outcome, extrusion rate and post‐obturation pain: A systematic review and meta‐analysis. Int Endod J. 2024;57:1021–42.
Osiri S, Banomyong D, Sattabanasuk V, Yanpiset K. Root Reinforcement after Obturation with Calcium Silicate–based Sealer and Modified Gutta-percha Cone. J Endod. 2018;44: 1843–8.
Dewi A, Upara C, Sastraruji T, Louwakul P. Effect of a heat‐based root canal obturation technique on push‐out bond strength of the
classical bioceramic and new HiFlow sealer. Aust Endod J. 2022;48:116–20.
Alkahtany SM, AlHussain AA, AlMthen HA, AlDokhi HD, Bukhary SM, Almohaimede AA, et al. Obturation quality of bioceramic sealers with different obturation techniques: a micro-CT evaluation. Sci Rep. 2024;14:31146.
Mobayed M, Ayoubi HR, Achour H, Alsayed Tolibah Y. Comparison of Different Obturation Techniques in the Dentinal Tubule Penetration of EndoSequence® Bioceramic Sealer HiFlowTM: An In-Vitro Study. Cureus. 2024;16:e71155.
Dasari L, Anwarullah A, Mandava J, Konagala R, Karumuri S, Chellapilla P. Influence of obturation technique on penetration depth and adaptation of a bioceramic root canal sealer. J Conserv Dent. 2020;23:505.
Li J, Chen L, Zeng C, Liu Y, Gong Q, Jiang H. Clinical outcome of bioceramic sealer iRoot SP extrusion in root canal treatment: a retrospective analysis. Head Face Med. 2022;18:28.
Stanley E, Strother KK, Kirkpatrick T, Jeong JW. Calcium Silicate–based Sealer Extrusion into the Mandibular Canal: 3 Different Recovery Outcomes—A Report of 3 Cases. J Endod. 2023;49:735–41.
Iwanaga J, Matsushita Y, Decater T, Ibaragi S, Tubbs RS. Mandibular canal vs. inferior alveolar canal: Evidence‐based terminology analysis. Clin Anat. 2021;34:209–17.
Sharaan MES, Abdulla AY, Ragab MH. Assessment of the relationship of the distance between mandibular first and second molars with the inferior alveolar canal and cortical bone plate in an Egyptian subpopulation: a CBCT study. Braz Oral Res. 2022;36:e033.
Chong BS, Quinn A, Pawar RR, Makdissi J, Sidhu SK. The anatomical relationship between the roots of mandibular second molars and the inferior alveolar nerve. Int Endod J. 2015;48:549–55.
Hiremath H, Agarwal R, Hiremath V, Phulambrikar T. Evaluation of proximity of mandibular molars and second premolar to inferior alveolar nerve canal among central Indians: A cone-beam computed tomographic retrospective study. Indian J Dent Res. 2016;27:312.
Aqili TM, Almuzaini ES, Aljohani AS, Saeedi AKA, Hammudah HA, Alassaf M, et al. Evaluation of the variations of mandibular molars and the distance from root apex to the inferior alveolar nerve in Saudi Sub-population: Threedimensional radiographic evaluation. Karobari MI, editor. PLOS ONE. 2025;20:e0317053.
Kawashima Y, Sakai O, Shosho D, Kaneda T, Gohel A. Proximity of the Mandibular Canal to Teeth and Cortical Bone. J Endod.
;42:221–4.
Do TT, Le LN, Tan LT, Dang ATT, Huynh DNK, Truong MH, et al. Investigating the characteristics of the mandibular canal in cone beam CT J Orthod Sci. 2024;13:45:1–6.
Oliveira ACS, Candeiro GTM, Pacheco da Costa FFN, Gazzaneo ID, Alves FRF, Marques FV. Distance and Bone Density between the Root Apex and the Mandibular Canal: A Cone-beam Study of 9202 Roots from a Brazilian Population. J Endod. 2019;45:538-542.e2.
Sanz JL, López-García S, García-Bernal D, Rodríguez-Lozano FJ, Forner L, Lozano A, et al. Comparative bioactivity and immunomodulatory potential of the new Bioroot Flow and AH Plus Bioceramic sealer: An in vitro study on hPDLSCs. Clin Oral Investig. 2024;28:195.
Sarunket C, Banomyong D, Vibulcharoenkitja P, Sutimuntanakul S. Radiopacity of Portland cement and calcium silicate-based cement with different mixed ratios of radiopacifiers. Eur Endod J. 2022;7:52–7.
Sanz JL, López‐García S, Rodríguez‐Lozano FJ, Melo M, Lozano A, Llena C, et al. Cytocompatibility and bioactive potential of
AH Plus Bioceramic Sealer: An in vitro study. Int Endod J. 2022;55:1066–80.
Lim M, Jung C, Shin DH, Cho Y bum, Song M. Calcium silicate-based root canal sealers: a literature review. Restor Dent Endod.
;45:e35.
Zamparini F, Prati C, Taddei P, Spinelli A, Di Foggia M, Gandolfi MG. Chemical-physical properties and bioactivity of new premixed
calcium silicate-bioceramic root canal sealers. Int J Mol Sci. 2022;23:13914.
Zordan-Bronzel CL, Esteves Torres FF, Tanomaru- Filho M, Chávez-Andrade GM, Bosso-Martelo R, Guerreiro-Tanomaru JM. Evaluation of physicochemical properties of a new calcium silicate–based sealer, Bio-C sealer. J Endod. 2019;45:1248–52.
Estivalet MS, De Araújo LP, Immich F, Da Silva AF, Ferreira NDS, Da Rosa WLDO, et al. Bioactivity potential of bioceramic-based root canal sealers: A scoping review. Life. 2022;12:1853.
Souza LCD, Neves GST, Kirkpatrick T, Letra A, Silva R. Physicochemical and biological properties of AH Plus bioceramic. J Endod.
;49:69–76.
Kwak SW, Koo J, Song M, Jang IH, Gambarini G, Kim HC. Physicochemical properties and biocompatibility of various bioceramic root
canal sealers: In vitro study. J Endod. 2023;49:871–9.
Mora A, García-Bernal D, Rodríguez-Lozano FJ, Sanz JL, Forner L, Ghilotti J, et al. Biocompatibility, bioactivity and immunomodulatory properties of three calcium silicate-based sealers: an in vitro study on hPDLSCs. Clin Oral Investig. 2024;28:416.
Bamrungwong J, Ratisoontorn C, Hiran-Us S, Sinsareekul C. Outcomes and prognostic factors of endodontically treated teeth with unintentional root canal sealer extrusion: A retrospective cohort study. J Dent. 2025;158:105804.
Algar J, Docampo-Vázquez C, Rico-Romano C, Boquete-Castro A, Obispo-Díaz C, Aragoneses JM. Randomised Clinical Trial: Effect of AH Plus and Neosealer Flo on Postoperative Pain and Healing of Periapical Lesions. Bioeng Basel Switz. 2025;12:376.
Zamparini F, Spinelli A, Cardinali F, Ausiello P, Gandolfi MG, Prati C. The Use of Premixed Calcium Silicate Bioceramic Sealer with Warm Carrier-Based Technique: A 2-Year Study for Patients Treated in a Master Program. J Funct Biomater. 2023;14:164.
Kangseng T, Banomyong D, Osiri S, Jantarat J. Outcomes and prognostic factors of endodontically treated teeth filled with calcium
silicate- or epoxy resin-based root canal sealers: A retrospective cohort study. Int Endod J. 2025;58:84–96.
López‐García S, Sánchez‐Bautista S, García‐ Bernal D, Lozano A, Forner L, Sanz JL, et al. Premixed calcium silicate‐based ceramic
sealers promote osteogenic/cementogenic differentiation of human periodontal ligament stem cells: A microscopy study. Microsc ResTech. 2024;87:1584–97.
Sanz JL, Guerrero‐Gironés J, Pecci‐Lloret MP, Pecci‐Lloret MR, Melo M. Biological interactions between calcium silicate‐based endodontic biomaterials and periodontal ligament stem cells: A systematic review of in vitro studies. Int Endod J. 2021;54:2025–43.
Elias VV, Lima RB, Lucisano MP, Araujo LDC, Pucinelli CM, Nelson‐Filho P, et al. Inflammatory response to bioceramic and epoxy resin‐based endodontic sealers implanted in mice subcutaneous tissue: An in vivo study. Microsc Res Tech. 2024;87:2447–58.
González-Martín M, Torres-Lagares D, Gutiérrez- Pérez JL, Segura-Egea JJ. Inferior alveolar nerve paresthesia after overfilling of endodontic sealer into the mandibular canal. J Endod. 2010;36:1419–21.
Mahmood H, Hoare J, Atkins S. Chemical neurotoxicity to the inferior alveolar nerve— A rare sequela of endodontic treatment.
Oral Surg. 2022;15:663–8.
Alves FRF, Dias MCC, Mansa MGCB, Machado MD. Permanent Labiomandibular Paresthesia after Bioceramic Sealer Extrusion: A Case Report. J Endod. 2020;46:301–6.
Tilotta-Yasukawa F, Millot S, El Haddioui A, Bravetti P, Gaudy JF. Labiomandibular paresthesia caused by endodontic treatment:
an anatomic and clinical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontology. 2006;102:e47–59.
Denio D, Torabinejad M, Bakland LK. Anatomical relationship of the mandibular canal to its surrounding structures in mature mandibles. J Endod. 1992;18:161–5.
Alves FR, Coutinho MS, Gonçalves LS. Endodontic-related facial paresthesia: systematic review. J Can Dent Assoc. 2014;80:e13.
Oliveira ACS, Candeiro GTM, Pacheco Da Costa FFN, Gazzaneo ID, Alves FRF, Marques FV. Distance and bone density between the root apex and the mandibular canal: A cone-beam study of 9202 roots from a Brazilian population. J Endod. 2019;45:538-542.e2.
Başa O, Dilek OC. Assessment of the risk of perforation of the mandibular canal by implant drill using density and thickness parameters: Assessment of the risk of perforation of the mandibular canal. Gerodontology. 2011;28:213–20.
Martins JFB, Scheeren B, Van Der Waal SV. The effect of unintentional AH-Plus sealer extrusion on resolution of apical periodontitis
after root canal treatment and retreatment— A retrospective case-control study. J Endod. 2023;49:1262–8.
Bastien AV, Adnot J, Moizan H, Calenda É, Trost O. Secondary surgical decompression of the inferior alveolar nerve after overfilling of
endodontic sealer into the mandibular canal: Case report and literature review. J Stomatol Oral Maxillofac Surg. 2017;118:389–92.
Fonseca B, Coelho MS, Bueno CEDS, Fontana CE, Martin ASD, Rocha DGP. Assessment of extrusion and postoperative pain of a bioceramic and resin-based root canal sealer. Eur J Dent. 2019;13:343–8.
Jaha HS. Hydraulic (Single Cone) Versus Thermogenic (Warm Vertical Compaction) Obturation Techniques: A Systematic Review.
Cureus. 2024;16:e62925.
Zamparini F, Lenzi J, Duncan HF, Spinelli A, Gandolfi MG, Prati C. The efficacy of premixed bioceramic sealers versus standard sealers
on root canal treatment outcome, extrusion rate and post-obturation pain: A systematic review and meta-analysis. Int Endod J.
;57:1021–42.
Deniz-Sungur D, Onur MA, Akbay E, Tan G, Daglı- Comert F, Sayın TC. Effects of calcium silicate cements on neuronal conductivity. Restor Dent Endod. 2022;47:e18.
López‐López J, Estrugo‐Devesa A, Jané‐Salas E, Segura‐Egea JJ. Inferior alveolar nerve injury resulting from overextension of an endodontic sealer: non‐surgical management using the GABA analogue pregabalin. Int Endod J. 2012;45:98–104.
Alves Silva EC, Tanomaru-Filho M, da Silva GF, Delfino MM, Cerri PS, Guerreiro-Tanomaru JM. Biocompatibility and Bioactive Potential of New Calcium Silicate-based Endodontic Sealers: Bio-C Sealer and Sealer Plus BC. J Endod. 2020;46:1470–7.
Scarano A, Di Carlo F, Quaranta A, Piattelli A. Injury of the inferior alveolar nerve after overfilling of the root canal with endodontic
cement: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontology. 2007;104:e56–9.
Köseogˇlu BG, Tanrıkulu Ş, Sübay RK, Sencer S. Anesthesia following overfilling of a root canal sealer into the mandibular canal: A case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontology. 2006;101:803–6.
Blanas N, Kienle F, Sàndor GKB. Injury to the inferior alveolar nerve due to thermoplastic gutta percha. J Oral Maxillofac Surg.2002;60:574–6.
Alonso-Ezpeleta O, Martin Pj, Lopez-Lopez J, Castellanos-Cosano L, Martin-Gonzalez J, Segura-Egea Jj. Pregabalin in the treatment of
inferior alveolar nerve paraesthesia following overfilling of endodontic sealer. J Clin Exp Dent. 2014;e197-202.
Scolozzi P, Lombardi T, Jaques B. Successful inferior alveolar nerve decompression for dysesthesia following endodontic treatment:
report of 4 cases treated by mandibular sagittal osteotomy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97:625–31.
Kim JE, Cho JB, Yi WJ, Heo MS, Lee SS, Choi SC, et al. Accidental overextension of endodontic filling material in patients with neurologic complications: a retrospective case series. Dentomaxillofac Radiol. 2016;45:20150394.
Management of endodontic injuries to the inferior alveolar nerve. Quintessence Int. 2016;47:581–7.
Byun S ‐H., Kim S ‐S., Chung H ‐J., Lim H ‐K., Hei W ‐H., Woo J ‐M., et al. Surgical management of damaged inferior alveolar nerve caused by endodontic overfilling of calcium hydroxide paste. Int Endod J. 2016;49:1020–9.
Ruparel NB, Ruparel SB, Chen PB, Ishikawa B, Diogenes A. Direct effect of endodontic sealers on trigeminal neuronal activity. J Endod. 2014;40:683–7.
Schultze-Mosgau S, Reich RH. Assessment of inferior alveolar and lingual nerve disturbances after dentoalveolar surgery, and of recovery of sensitivity. Int J Oral Maxillofac Surg. 199;22:214–7.
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