The Relationship between Blood Lipid Levels (Triglyceride, Cholesterol, LDL, HDL) and GFR for Assessing Kidney Disease Risk in Type 2 Diabetes Patients Samchai Hospital, Kalasin Province
Keywords:
Type 2 diabetes, Blood lipids, Chronic kidney diseaseAbstract
This research aimed to investigate the relationship between blood lipid levels (Triglyceride, Cholesterol, LDL, HDL) and GFR, and to assess the risk of chronic kidney disease in type 2 diabetes patients at Samchai Hospital, Kalasin Province. The study employed a retrospective design, collecting data from 327 type 2 diabetes patients who received treatment between 2021 and 2023. Systematic random sampling was used to select participants. Data were collected using electronic medical records and analyzed using descriptive statistics, correlation analysis, and multiple logistic regression.
The results showed a negative correlation between triglyceride levels and eGFR (r = -0.17, p < 0.05), while HDL-cholesterol demonstrated a positive correlation (r = 0.27, p < 0.05). Patients with triglyceride levels ≥ 150 mg/dl had a 2.37 times higher risk of kidney disease (95% CI: 1.12-5.01, p = 0.02), and those with HDL-cholesterol levels < 40 mg/dl had a 2.82 times higher risk (95% CI: 1.33-5.97, p = 0.01) compared to patients with normal levels. In conclusion, high triglyceride levels and low HDL-cholesterol levels were identified as significant risk factors for kidney disease in type 2 diabetes patients.
References
International Diabetes Federation. IDF Diabetes Atlas (10th ed.) [Internet]. 2021 [cited 2021 Jul 10]. Available from: https://diabetesatlas.org/atlas/tenth-edition/
National Kidney Foundation. Diabetes and Kidney Disease: What to Expect [Internet]. 2020 [cited 2020 May 5]. Available from: https://www.kidney.org/atoz/content/diabetes
สมาคมโรคไตแห่งประเทศไทย. รายงานสถานการณ์โรคไตในประเทศไทย [อินเทอร์เน็ต]. 2563 [เข้าถึงเมื่อ 10 พ.ค. 2567]. เข้าถึงได้จาก: https://www.nephrothai.org/รายงานสถานการณ์โรคไตในประเทศไทย
ศูนย์ข้อมูลสารสนเทศด้านสุขภาพ จังหวัดกาฬสินธุ์. อุบัติการณ์ของโรคไตเรื้อรัง อำเภอสามชัย พ.ศ. 2564-2566 [อินเทอร์เน็ต]. 2566 [เข้าถึงเมื่อ 10 เม.ย. 2567]. เข้าถึงได้จาก: https://ksn.hdc.moph.go.th/hdc/reports/page.php?cat_id=e71a73a77b1474e63b71bccf727009ce
Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382(9888):260-72.
Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int. 2011;80(12):1258-70.
Wang V, Vilme H, Maciejewski ML, Boulware LE. The economic burden of chronic kidney disease and end-stage renal disease. Semin Nephrol. 2020;40(3):283-93.
Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;32(1):193-203.
Collins R, Armitage J, Parish S, Sleight P, Peto R. Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions. Lancet. 2016;363(9411):757-67.
Jenkins AJ, Lyons TJ, Zheng D, Otvos JD, Lackland DT, McGee D, et al. LDL particle subclasses, LDL particle size, and carotid atherosclerosis: The Insulin Resistance Atherosclerosis Study (IRAS). Diabetes Care. 2019;38(8):1495-500.
Zhou L. Relationships among the Levels of Blood Lipid and Glycosylated Hemoglobin, Insulin Resistance and β-Cell Function in Patients with Type 2 Diabetes. Chin J Clin Med. 2012.
GozifMohammed N, MansourAbdulnabi H, Al-Arabi F, Madhukar M. Correlation between Glycated Haemoglobin Values and the Lipid Profile in Type 2 Diabetic Patients. J Diabetes Metab. 2021;12:1-2.
Wang L, Yan N, Zhang M, Pan RR, Dang Y, Niu Y. The association between blood glucose levels and lipids or lipid ratios in type 2 diabetes patients: A cross-sectional study. Front Endocrinol (Lausanne). 2022;13:876.
Cochran WG. Sampling techniques. 3rd ed. New York: John Wiley & Sons; 1977
Russo GT, De Cosmo S, Viazzi F, Pacilli A, Ceriello A, Genovese S, et al. Plasma Triglycerides and HDL-C Levels Predict the Development of Diabetic Kidney Disease in Subjects With Type 2 Diabetes: The AMD Annals Initiative. Diabetes Care. 2016;39(12):2278-87.
Chang YH, et al. High-density lipoprotein cholesterol and the risk of nephropathy in type 2 diabetic patients. Nutr Metab Cardiovasc Dis. 2013;23(8):751-757.
Zoppini G, Targher G, Chonchol M, Ortalda V, Negri C, Stoico V, et al. Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function. Diabetes Care. 2012;35(1):99-104.
Bulum T, et al. Serum lipids and lipid accumulation product in relation to glomerular filtration rate in patients with type 2 diabetes. Endocrinologist. 2013;23(1):16-20.
Tsimihodimos V, et al. Dyslipidemia associated with chronic kidney disease. Open Cardiovasc Med J. 2011;5:41-48.
