Relationship of fasting blood sugar, Hemoglobin A1c and serum lipid profile level with glomerular filtration rate in diabetes care clinics at Sena Hospital, Phra Nakhon Si Ayutthaya

Abstract

     This retrospective study aimed to study of the relationship between FBS, HbA1c, Cholesterol, Triglycerides, LDL Cholesterol, and HDL Cholesterol and eGFR and to identify factors for developing a risk score to predict a decline in the glomerular filtration rate. Data were collected from patients with diabetes mellitus or those undergoing annual health check-ups Sena Hospital, Phra Nakhon Si Ayutthaya. Data were collected from the hospital's database or from the VITROS 5600 Integrated System, a clinical chemistry and immunoassay analyzer, between October 1, 2023, and September 30, 2024. A total of 1,852 participants were included in the study. Data was analyzed using statistical software, with descriptive statistics such as frequency, percentage, minimum-maximum, mean, and standard deviation. Inferential statistics included the Chi-Square Test, and. logistic regression with significant level of p-value < 0.05

     Results: The study included 1,852 healthy checkup and diabetic patients (41.2% male, 58.8% female) with a mean age of 63.31 years. The mean FBS and HbA1c levels were 141.66 mg/dl and 7.27%, respectively. Mean lipid profiles were as follows: cholesterol, 186.42 mg/dl; triglycerides, 145.19 mg/dl; LDL cholesterol, 108.08 mg/dl; and HDL cholesterol, 49.30 mg/dl. The mean estimated eGFR was 73.16 ± 27.26 mL/min/1.73 m². A multiple logistic regression analysis revealed significant relationships between various factors and eGFR. In a sample group, those aged 45 years or older had a 6.5 times higher risk of decreased eGFR compared to those younger than 45. Patients aged 66 years or older had an even higher risk, with a 9.9 times increased likelihood of decreased eGFR. Furthermore, patients with triglyceride levels of 150 mg/dL or higher were 1.6 times more likely to have a decreased eGFR compared to those with normal triglyceride levels. Females had a 1.67 times higher risk of decreased eGFR compared to males. Additionally, patients with HbA1c levels of 7% or higher had a 1.38 times increased risk of decreased eGFR compared to those with levels below 7% (p<0.01)