First-line Tuberculosis in Pulmonary Drug Resistance Patterns with Drug Sensitivity Testing in Sputum Specimens among New Pulmonary Tuberculosis Patients in the Second Regional Health

Abstract

           This research was a retrospective study aimed to study the first-line drug resistance pattern of pulmonary tuberculosis from sputum samples of new cases in the second regional  health , 2019-2021.  Testing was performed at the Office of  Disease  Prevention and  Control  2 , Phitsanulok  Province.  There were drug susceptibility tests for Isoniazid, Rifampicin, Streptomycin, Ethambutol  in a total of 588  samples , mostly male patients  76.19%.  17.00% , 0.34 , 0.34 , 4.59% , respectively  ,  4.76%   of  Isoniazid  plus  Streptomycin  resistant  tuberculosis , 0.17%  of  Isoniazid  plus   Ethambutol   resistant ,   equal  to   Rifampicin   plus Streptomycin   resistant  tuberculosis  and  MDR-TB  resistant  to  Isoniazid  plus Rifampicin 0.85% , resistant form Isoniazid-resistant TB (HR-TB) , 21.94% , was found mainly in late  adult  patients (45-64 years of age) and the resistant form. Rifampicin-resistant TB (RR-TB, MDR-TB) found 1.36%, mostly in late adults (45-64 years old) and the elderly adults (65 years old and over).

           The first-line drug resistance pattern of pulmonary tuberculosis  showed both single-drug-resistant strains. Two drug resistant pathogens and  multidrug-resistant pathogens  Concomitant  isoniazid and  rifampicin resistant strains may cause  MDR-TB  multidrug  resistance and severe  multidrug resistance  XDR-TB  may be occurred in the future.