The Effectiveness of Oroxylum indicum Topical Solution and Calamine Lotion for Treatment of Itchy Skin

Abstract

Oroxylum indicum bark contains bioactive flavonoids, including oroxylin A and baicalein, with antioxidant, anti-inflammatory, analgesic, antimicrobial, and antiallergic properties. This study is a Single-Blinded Randomized Controlled Trial. In this trial, we aim to evaluate the effectiveness of Oroxylum indicum topical solution in reducing itchiness, compared with calamine lotion. Eighty participants were randomly assigned to two groups (n = 40 each): one received the Oroxylum indicum topical solution, and the other received calamine lotion. Baseline itchiness severity was assessed using a standardized itchiness scale. An irritation test was conducted, followed by
a 30-minute observation period. Participants applied their assigned treatment thrice daily for seven days. itchiness severity was reassessed at 30 minutes, 1 hour, 1 day, 3 days, and 7 days post-application. Mean itchiness scores between groups were statistically analyzed at each time point. Results indicated that the Oroxylum indicum topical solution significantly reduced itchiness compared to calamine lotion at 30 minutes, 1 hour, and 1 day post-application (p < 0.05). However, no significant difference was observed on days 3 and 7. In conclusion, the Oroxylum indicum topical solution demonstrated superior short-term efficacy in alleviating itchiness compared to calamine lotion in one day. And the mean satisfaction scores of the two groups were not significantly different.