PHYTOCHEMICALS AND THEIR INFLUENCE ON TELOMERE LENGTH
Keywords:
Phytochemicals, Telomere, Anti-agingAbstract
The aging process or gradual functional decline of the body according to age is associated with the development of age-related diseases such as cancer, heart disease, memory loss, and diabetes. This phenomenon can be explained by various molecular-level mechanisms, for instance, cellular senescence, mitochondrial disorders, free radical, oxidative stress, inflammation, hormonal fluctuations and telomere attrition. In order to achieve optimal health, numerous approaches can be used such as exercise, food management, medication, taking dietary supplement and medical treatment. Some methods are accepted as effective treatments while others still lack clear evidence on their effectiveness.
One effective mechanism for life extension is the maintenance of telomeres length during cell division by the activation of telomerase. This mechanism was discovered in 2009 by Blackburn et al. leading to a lot of medical research, potential treatments, medications, dietary supplements, and medical technologies that aim to extend the human lifespan. However, the most effective method for the maintenance of telomeres length is food management. Nutrients and natural compounds in food have the potential to maintain and lengthen telomeres. Plants, especially herbs, contain a variety of phytochemicals. They have both primary metabolites and secondary metabolites which are associated with shortened telomere length; for example, phenolic, alkaloid, and terpenoid compounds. In this research article, we present the examples of phytochemicals having the potential to delay the aging process and prevent age-related diseases through telomere-related mechanisms. This information can be used to create a list of foods, beverages, and supplements to promote anti-aging and better health, ultimately leading to a longer and healthier life.
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“ข้าพเจ้าและผู้เขียนร่วม (ถ้ามี) ขอรับรองว่า บทความที่เสนอมานี้ยังไม่เคยได้รับการตีพิมพ์และไม่ได้อยู่ระหว่างกระบวนการพิจารณาลงตีพิมพ์ในวารสารหรือแหล่งเผยแพร่อื่นใด ข้าพเจ้าและผู้เขียนร่วมยอมรับหลักเกณฑ์การพิจารณาต้นฉบับ ทั้งยินยอมให้กองบรรณาธิการมีสิทธิ์พิจารณาและตรวจแก้ต้นฉบับได้ตามที่เห็นสมควร พร้อมนี้ขอมอบลิขสิทธิ์บทความที่ได้รับการตีพิมพ์ให้แก่สถาบันการจัดการปัญญาภิวัฒน์หากมีการฟ้องร้องเรื่องการละเมิดลิขสิทธิ์เกี่ยวกับภาพ กราฟ ข้อความส่วนใดส่วนหนึ่งและ/หรือข้อคิดเห็นที่ปรากฏในบทความข้าพเจ้าและผู้เขียนร่วมยินยอมรับผิดชอบแต่เพียงฝ่ายเดียว”
