Relationship between Time Initial Administration of Norepinephrine and 24-hour Mortality in Septic Shock at Emergency Department Chiangrai Prachanukroh Hospital, Thailand
DOI:
https://doi.org/10.14456/jemst.2022.5Keywords:
mortality, septic shock, norepinephrineAbstract
Septic shock is an important global healthcare problem with a high mortality rate, causing unsatisfied outcome. The recent survival sepsis campaign bundle 2018 update recommended to apply vasopressors within the first hour to achieve mean arterial pressure ≥65 mm Hg for improved outcome. This study aimed to evaluate the relationship between time of initial administration of vasopressor and 24-hour mortality in septic shock patients. It was conducted as a retrospective cohort study using data from 262 adult septic shock patients treated at Emergency Department of Chiangrai Prachanukhroh Hospital during January 2016 – January 2021. The primary outcome was the relationship between time initial Norepinephrine and death in 24-hour. It was found that among 262 patients, 114 were administered norepinephrine within 60 minutes, average time to initiate Norepinephrine was 42±15.87) minutes competed to the average time to initiate norepinephrine in the late group which was 93±37.73 minutes (p<0.001). This study found there was no statistically significant in mortality in 24-hour in septic shock patients [crude RR=0.89, (95%CI=0.43-1.85, p=0.759)]. In conclusion, time to initiate norepinephrine within 60 minutes in septic shock patients at emergency department of Chiangrai Prachanukroh Hospital was not associated with 24-hour mortality.
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