The effect of lidocaine combine with propofol on the dose of propofol required for colonoscopy : a randomized controlled trial
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Abstract
Colonoscopy is a non-invasive procedure used to examine the gastrointestinal system. Moderate to deep sedation enhances patient comfort, reduces anxiety, and allows for longer procedures, increasing satisfaction for patients and endoscopists. The use of high doses of propofol may cause complications such as hypoxia, apnea, hypotension, and upper airway obstruction. The concurrent use of lidocaine with propofol has been shown to reduce the required dose of propofol. This study aimed to study the effects of lidocaine combined with propofol on the dose of propofol required for colonoscopy and the incidence of respiratory and cardiovascular complications. This study is a prospective randomized controlled trial that included 52 patients aged 18–80 years who underwent colonoscopy at Uthumphon Phisai Hospital from August to October 2024. Participants were divided into two groups: Group L (lidocaine) and Group P (propofol). The amount of propofol used in both groups was compared, as well as the incidence of respiratory and cardiovascular complications during and after the procedure. Data were collected using anesthesia records and pre-anesthesia evaluation forms. Statistical analysis was performed using Student's t-test to compare the dosage of propofol and the chi-square test or Fisher's exact test used for categorical data.
The results showed that lidocaine combined with propofol significantly reduced the propofol required for sedation. Lidocaine group (158.85 ± 53.65 mg) was significantly lower than that in the propofol group (261.54 ± 78.16 mg) with p-value < 0.001 (Student's t-test). Patients in the lidocaine group experienced less movement during the procedure, fewer airway management maneuvers, and shorter recovery times compared to the propofol group. Additionally, patient and physician satisfaction was higher in the lidocaine group than in the propofol group.
This study concludes that the combination of lidocaine with propofol is effective in significantly reducing the propofol required for sedation without causing complications from the use of lidocaine.
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