Shear wave elastography results correlate with FIB-4 index and NAFLD fibrosis score to predict liver fibrosis in overweight patients who increase risk for non-alcoholic fatty liver disease, Uthumphon phisai District, Sisaket Province.
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Abstract
Overnutrition is a risk factor for fatty liver disease, which can lead to hepatitis and liver fibrosis. The standard diagnostic method for fatty liver disease is liver biopsy, but it is invasive and has side effects, so it is not popular. The sensitivity of ultrasound diagnosis of fatty liver disease in obese people is lower than in the general population, which increases the risk of not being diagnosed and treated appropriately. This is a cross-sectional analytical study. The objective of this study was to analyze the consistency of using ultrasound elastography to assess the severity of liver fibrosis compared with the FIB-4 index and NAFLD fibrosis score. The study included 219 patients with a body mass index (BMI) of 25 kg/m2 or higher. The ultrasound elastography was compared with the FIB-4 index and NAFLD fibrosis score. Data were collected using questionnaires, ultrasound examinations, and laboratory test results. Data were collected between January and March. Until March 2024, the data were analyzed using descriptive statistics, including mean, frequency, percentage, and standard deviation for continuous variables with normal distribution. The consistency and relationship of ultrasound results with FIB-4 index, NAFLD fibrosis score, and baseline factors of the participants were tested using Spearman's rank correlation coefficient, Chi-Square test, and one-way ANOVA, with statistical significance set at p-value<0.05.
The results of the study found that a total of 219 participants found that the severity of fibrosis obtained from ultrasound examination was inversely related to the FIB-4 index, with a correlation coefficient of -0.165, p=0.015, and no statistically significant relationship was found with the NAFLD fibrosis score (p-value = 0.734). Factors that were associated with the severity of fibrosis from ultrasound examination in the same direction were body mass index and diabetes/prediabetes, with a correlation coefficient of 0.287, p<0.001, and 0.189, p=0.005, respectively.
In conclusion, the severity of fibrosis obtained by ultrasound examination was inversely related to the FIB-4 index and was not related to the NAFLD fibrosis score.
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เนื้อหาและข้อมูล (เขียนข้อกำหนด)
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